Anti-GABRR1 Antibody

Raised in rabbit, this polyclonal IgG reagent from Antibodies.com targets the rho1 (ρ1) subunit of the GABA-A receptor — a ligand-gated chloride channel central to rapid inhibitory neurotransmission. The unconjugated antibody is supplied as 50 µL of antisera in a single-use vial and is validated for Western blot detection of endogenous GABRR1 in mouse and rat tissue samples.

GABRR1 is most abundantly expressed in retinal bipolar cells, where it shapes GABAergic signaling within the visual pathway, with lower but detectable levels in other CNS regions. The polyclonal format recognizes multiple epitopes on the target, supporting consistent band detection across denatured lysate preparations. Working dilutions should be titrated empirically for each lysate and detection system; HRP-conjugated secondary antibodies and ECL-based visualization are commonly used to reveal specific bands.

For continuous use, store at −20 °C and avoid repeated freeze-thaw cycles to preserve antibody activity. Intended for research use only, the reagent fits laboratory workflows probing ion channel subunit composition, retinal physiology, GABAergic signaling mechanisms, and broader neuroscience questions about inhibitory neurotransmission.