Anti-GABRB3 Antibody

The gamma-aminobutyric acid type A receptor beta 3 subunit (GABRB3) is a ligand-gated chloride channel component that mediates fast inhibitory synaptic transmission throughout the central nervous system. This rabbit polyclonal IgG reagent from Antibodies.com was raised against a GABRB3-specific immunogen and affinity purified to reduce non-specific background. It is validated for Western blot on human samples and supplied unconjugated at 50 µl, ready for use with HRP- or fluorophore-conjugated secondary reagents in standard chemiluminescent or fluorescence detection workflows.

GABRB3 is encoded within the 15q11-q13 imprinted region, and mutations or copy-number changes at this locus have been linked to developmental and epileptic encephalopathies, Angelman syndrome, Prader-Willi syndrome, and idiopathic generalized epilepsies. The subunit assembles with alpha, gamma, and other beta subunits to form pentameric GABA-A receptors that respond to gamma-aminobutyric acid, benzodiazepines, barbiturates, and neurosteroids at the cell surface, supporting its relevance to studies of inhibitory neurotransmission and receptor pharmacology.

Handling and storage: briefly centrifuge the vial before opening, aliquot upon arrival, and store at -20 °C or -80 °C for long-term use; avoid repeated freeze-thaw cycles, and protect from light if the working dilution is held at 4 °C. Each lot is quality controlled for target-specific recognition in Western blot and for reduced cross-reactivity against the closely related GABA-A receptor beta subunits. This primary antibody is for research use only and is well suited to investigations of human neural tissue and cultured cell models where mapping receptor subunit expression supports work on neurodevelopmental and epileptic disorders.