Anti-GABRB3 Antibody

Raised in rabbit as a polyclonal IgG preparation, this unconjugated reagent from Antibodies.com specifically recognizes the beta-3 subunit of the human GABA-A receptor (GABRB3), a ligand-gated chloride channel that mediates fast inhibitory neurotransmission in the central nervous system. The antibody is supplied in a 100 µL vial and is validated for Western blot detection of GABRB3 in human samples.

GABRB3 is widely studied in neurobiology because variants in the gene are linked to neurodevelopmental disorders, including Angelman syndrome, Prader-Willi syndrome, childhood absence epilepsy, and idiopathic autism spectrum disorder. Researchers working on inhibitory synapse biology, neuronal receptor trafficking, and the molecular pathology of these conditions use anti-GABRB3 antibodies to assess subunit expression in brain-derived lysates by Western blot.

Because the target is a membrane-bound ion channel subunit, lysate preparation for Western blot benefits from buffers that preserve membrane proteins, and the unconjugated format lets researchers pair the antibody with their preferred HRP- or fluorophore-conjugated secondary reagent.