Anti-GABRB2 Antibody

The GABRB2 gene encodes the beta-2 subunit of the type A gamma-aminobutyric acid receptor, a pentameric ligand-gated chloride channel that mediates the majority of fast inhibitory neurotransmission in the mammalian central nervous system.

This polyclonal reagent, raised in rabbit, recognizes the human, mouse, and rat forms of the protein and is supplied as an unconjugated 100 µl aliquot suitable for western blot and immunohistochemistry workflows on fixed tissue sections or extracted lysates.

GABRB2 is broadly expressed in neurons of the cortex, hippocampus, thalamus, and cerebellum, and altered subunit composition has been associated with idiopathic generalized epilepsy, autism spectrum disorder, and certain neurodevelopmental phenotypes. Researchers studying inhibitory synapse biology, GABAergic signaling, or subunit-specific receptor pharmacology commonly use anti-GABRB2 antibodies to localize the beta-2 subunit within brain regions, confirm expression in heterologous systems, or quantify changes following genetic or pharmacological manipulation.

The reagent is provided by Antibodies.com as a polyclonal rabbit host preparation with no fluorophore or enzyme conjugate attached, leaving the choice of secondary detection chemistry to the end user.