Anti-GABP-beta1 Antibody

Raised in rabbit, this unconjugated polyclonal antibody from Antibodies.com targets the beta-1 subunit of GA-binding protein (GABP-beta1), a nuclear transcription factor that assembles with the GABP-alpha subunit to bind purine-rich promoters and drive expression of nuclear-encoded mitochondrial genes involved in respiratory chain function. The reagent is validated for western blot, immunohistochemistry, and immunofluorescence on human samples, making it a practical probe for studies of mitochondrial biogenesis, oxidative phosphorylation regulation, and oncogenic signaling pathways such as HER2-driven breast cancer where GABP controls ERR-alpha activity. Supplied as 100 µl of unconjugated serum fraction, the antibody gives laboratories flexibility for HRP, fluorophore, or biotin secondary labeling, and supports immunoblot detection as well as immunofluorescence imaging of predominantly nuclear protein distribution. Researchers investigating respiratory chain disorders, mitochondrial transcription programs, or nuclear receptor cross-talk will find this reagent fits workflows including IHC on formalin-fixed paraffin-embedded tissue, IF on cultured cells, and western blot of nuclear extracts prepared by standard lysis protocols.