Anti-GAB1 Antibody

This unconjugated rabbit polyclonal primary antibody from Antibodies.com specifically recognizes GRB2-associated binding protein 1 (GAB1), a large multisite docking adapter that links activated receptor tyrosine kinases to downstream RAS-MAPK and PI3K-AKT signaling cascades. Supplied as 100 µl of polyclonal antiserum, the reagent is validated for Western blot (WB) and immunofluorescence (IF) workflows and shows reactivity against Human, Mouse, and Rat samples.

GAB1 functions as a scaffold protein recruited to the plasma membrane through its N-terminal pleckstrin homology (PH) domain, where it becomes tyrosine-phosphorylated at multiple sites to create binding platforms for SH2-domain effectors such as SHP2, GRB2, and PI3K. Researchers use this reagent to probe growth factor, cytokine, and integrin signaling networks in studies of cell proliferation, migration, differentiation, and survival, as well as in tumor biology contexts where aberrant GAB1 activity has been implicated in breast cancer, hepatocellular carcinoma, and other malignancies.

The unconjugated format allows flexible pairing with user-selected secondary labels, and the polyclonal rabbit host provides broad epitope coverage of the target protein. The reagent is shipped as a 100 µl vial that supports multiple immunoblotting and imaging experiments.