Anti-G3BP1 Antibody

G3BP1 (Ras GTPase-Activating Protein-Binding Protein 1) is a multifunctional RNA-binding protein central to stress granule assembly and the cellular response to translational stress. This unconjugated rabbit polyclonal IgG antibody, supplied by Antibodies.com as a 200 µl liquid preparation, recognizes endogenous G3BP1 and is validated for western blot and immunofluorescence workflows.

The target participates in mRNA metabolism, translational silencing under oxidative or viral stress, and innate immune signaling, with documented roles in oncogenesis, viral replication (notably picornavirus 3C protease cleavage), and neurodegenerative disease models. Raised in rabbit and affinity-purified as a polyclonal reagent, the antibody binds the native G3BP1 protein with reactivity confirmed against human, mouse, and duck samples, enabling cross-species studies in cell culture and tissue preparations.

Use the unconjugated format to pair with custom fluorophores, HRP conjugates, or biotin for immunoprecipitation, immunoblotting, or co-localization experiments. The reagent is intended for research use only and supports applications ranging from subcellular stress granule mapping and signaling pathway dissection to studies of translation initiation, RNA-protein interaction networks, and viral host-factor biology in cancer, virology, and neuroscience.