Anti-FZR1 Antibody

Raised in rabbit, this unconjugated polyclonal antibody recognizes FZR1 (Fizzy-related protein 1), also known as CDH1, a WD40-repeat activator of the anaphase-promoting complex/cyclosome (APC/C). FZR1 directs APC/C-mediated ubiquitination of mitotic regulators such as cyclin B1 and securin during late mitosis and G1, making it a useful reagent for cell-cycle exit, mitotic checkpoint, and APC/C activity studies.

From Antibodies.com, the antibody is validated for Western blot (WB) and immunofluorescence (IF) workflows and cross-reacts with Human, Mouse, and Rat samples, supporting comparative cell-cycle research across human cell lines and rodent models. Supplied as a 100 µl liquid aliquot of unconjugated antiserum, it is suited to immunoblotting of endogenous FZR1 levels and to IF localization experiments in dividing or differentiated cells.

The polyclonal format offers broader epitope coverage than monoclonal alternatives, which helps when probing FZR1 isoforms, post-translational modifications, or changes in protein abundance across the cell cycle. Refrigerate the vial upon arrival and avoid repeated freeze-thaw cycles to preserve antibody activity.