Anti-FZR1 Antibody

FZR1, also known as Cdh1, functions as a substrate-specific activator of the anaphase-promoting complex/cyclosome (APC/C), and this rabbit polyclonal antibody from Antibodies.com is raised against the full-length human protein for detection in research applications. FZR1 drives ubiquitin-dependent degradation of mitotic regulators including cyclin B1 and securin, governing the metaphase-to-anaphase transition and the maintenance of G1 phase. The unconjugated reagent ships as a 100 µl liquid aliquot and is validated for western blot and immunohistochemistry on human samples. Investigators studying cell cycle exit, mitotic checkpoint fidelity, APC/C regulation, and chromosome segregation use this reagent to examine FZR1 abundance and turnover in cultured mammalian cells and in fixed tissue sections. Polyclonal reactivity provides broad epitope coverage, supporting detection of full-length FZR1 alongside catalogued isoforms and post-translationally modified forms. The reagent is for research use only and is compatible with standard HRP- or fluorescence-based secondary detection depending on the workflow chosen.