Anti-FZD4 Antibody

Generated in rabbit and supplied by Antibodies.com at 100 µl, this unconjugated polyclonal reagent specifically recognizes Frizzled-4 (FZD4), a seven-transmembrane Wnt receptor that drives canonical β-catenin signaling during retinal angiogenesis and blood-vessel development. Validated for western blot and immunohistochemistry, the antibody detects human and mouse FZD4 in tissue sections and lysate preparations, supporting studies of Wnt pathway biology and ocular vascular disease.

Because loss-of-function mutations in FZD4 are linked to Familial Exudative Vitreoretinopathy (FEVR) and Norrie disease, the reagent is useful for retinal vasculature research, angiogenic signaling dissection, and characterization of Wnt-pathway components in developmental and disease models. The unconjugated format lets researchers pair the primary with their preferred secondary reagents for chromogenic, fluorescent, or chemiluminescent readout as the experimental design requires.