Anti-FZD1 Antibody

This polyclonal antibody from Antibodies.com targets Frizzled-1 (FZD1), a seven-transmembrane G-protein-coupled receptor that serves as a Wnt ligand-binding component in the canonical and non-canonical Wnt signaling cascades. Raised in rabbit and purified as an IgG preparation, the reagent is supplied unconjugated at 100 µl per vial, ready for direct incubation with HRP- or fluorophore-tagged secondary antibodies in standard Western blot workflows.

The antibody has been validated to detect endogenous FZD1 in human, mouse, and rat samples, supporting comparative studies of Wnt pathway activity across model organisms. Because FZD1 participates in β-catenin-dependent transcription and planar cell polarity signaling, this reagent is commonly cited in research on embryonic axis specification, osteoblast differentiation, neural progenitor behavior, and tumor cell migration where altered Wnt activity is implicated.

For best results, aliquot upon first thaw to limit freeze-thaw cycles, store at -20 °C in working volumes, and avoid prolonged exposure to light. The unconjugated format offers flexibility in assay design, accommodating custom labeling for immunohistochemistry, immunoprecipitation, or proximity ligation workflows when paired with appropriate secondary reagents.