Anti-FXYD2 Antibody

FXYD2, the gamma regulatory subunit of the Na+/K+-ATPase, is a small single-pass transmembrane protein that modulates sodium and potassium pump activity in polarized epithelia. This unconjugated rabbit polyclonal reagent from Antibodies.com is supplied at 1 mg/ml in phosphate buffered saline (PBS) with 0.05% sodium azide at approximately pH 7.2, and ships as a 100 µl vial suited for multiple western blot experiments.

FXYD2, also referenced in the literature as ATP1G1, is expressed predominantly in the kidney, where it fine-tunes Na+/K+-ATPase function along renal tubules and contributes to renal magnesium handling. Researchers investigating hypomagnesemia, tubular ion transport, and membrane protein regulation rely on anti-FXYD2 reagents to detect this subunit across tissue lysates from human, mouse, and rat samples, supporting translational studies of renal physiology and electrolyte homeostasis.

For western blot application, dilute the antibody in blocking buffer using an established immunoblotting protocol, store refrigerated to preserve activity, and aliquot if repeated freeze-thaw cycles are anticipated. The polyclonal format provides recognition of multiple epitopes on FXYD2, which can strengthen signal robustness on western blot membranes relative to monoclonal alternatives, and the unconjugated formulation leaves the choice of secondary antibody and detection chemistry entirely to the user.