Anti-FUT8 Antibody

Raised in rabbit against human alpha-(1,6)-fucosyltransferase, this unconjugated polyclonal IgG reagent from Antibodies.com is supplied as a 200 µl vial and is validated for Western blot and immunohistochemistry. The antibody selectively recognizes FUT8, a Golgi-resident glycosyltransferase that catalyzes core fucosylation of N-linked glycoproteins. The modification modulates antibody-dependent cellular cytotoxicity, epidermal growth factor receptor signaling, and is frequently dysregulated in hepatocellular carcinoma, non-small cell lung cancer, and breast cancer tissues, making FUT8 a biomarker of interest in tumor biology and glycobiology research. Researchers probing epithelial-mesenchymal transition, IgG-Fc glycosylation, or cancer cell surface remodeling can apply the reagent to whole-cell lysates for WB detection of the ~66 kDa FUT8 band, or to formalin-fixed paraffin-embedded sections for IHC localization studies. Aliquot upon receipt and minimize freeze-thaw cycles to preserve working stability across the shelf life.