Anti-FUT8 Antibody

This polyclonal antibody from Antibodies.com targets FUT8 (α-1,6-fucosyltransferase 8), the enzyme responsible for adding core fucose residues to N-linked glycans on glycoproteins including IgG. Raised in rabbit and supplied as an unconjugated IgG preparation in 100 µl format, the reagent is validated for Western blot and immunohistochemistry on human samples, making it useful for glycobiology and immunology labs investigating core fucosylation patterns. Core fucosylation of the IgG Fc region modulates antibody-dependent cellular cytotoxicity, so the antibody supports studies of therapeutic antibody effector function, glycoengineering, and disease contexts where altered fucosylation has been reported, including melanoma and hepatocellular carcinoma. Researchers also use it to map FUT8 expression across normal and tumor tissues via IHC, and to detect the endogenous protein in cell lysates by WB. The polyclonal format provides recognition of multiple epitopes on FUT8, an advantage when working with a Golgi-resident enzyme that can be challenging to detect.