Anti-FSHB Antibody

This rabbit polyclonal reagent from Antibodies.com targets the beta subunit of human follicle-stimulating hormone (FSHB), a glycoprotein secreted by gonadotroph cells of the anterior pituitary that drives gonadal function in both sexes. The unconjugated IgG is supplied at 200 µL and is validated for Western blot detection of FSHB across human, mouse, and rat samples, supporting comparative studies in reproductive and endocrine biology. Researchers apply this primary antibody to investigate spermatogenesis and ovarian follicle maturation, to characterize gonadotroph populations in pituitary tissue, and to probe FSHB expression changes associated with infertility, hypogonadotropic hypogonadism, and hormonal cycle stages. To preserve activity, the antibody should be aliquoted upon arrival and handled in a way that limits freeze-thaw cycles, a standard precaution for polyclonal IgG preparations raised in rabbit. FSHB is the subunit that confers biological and immunological specificity to the mature FSH heterodimer, distinguishing it from related glycoprotein hormones such as LH, TSH, and hCG, and it is the locus of clinical mutations linked to disrupted fertility. Pair the reagent with HRP- or fluorophore-conjugated secondary antibodies matched to the rabbit host for clean chemiluminescent or fluorescent Western blot readouts, or adapt it for downstream validation by immunoprecipitation of pituitary or gonadal lysates.