Anti-FRZB Antibody

FRZB (Frizzled-Related Protein B, also called secreted Frizzled-Related Protein 3) is a secreted Wnt antagonist that modulates canonical and non-canonical Wnt signaling by sequestering Wnt ligands away from Frizzled receptors. This unconjugated rabbit polyclonal reagent from Antibodies.com is supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, packaged as a 100 µl vial that is convenient to aliquot and store at -20 °C to limit freeze-thaw degradation. The antibody is validated for western blot and immunohistochemistry across human, mouse, and rat specimens, supporting research on chondrogenesis, osteoarthritis susceptibility, skeletal development, and tumor microenvironments where FRZB is frequently downregulated. Polyclonal recognition of multiple epitopes aids detection of the full-length glycoprotein and its proteolytic fragments in cartilage and bone lysates.