Anti-Frizzled-9 Antibody

Frizzled-9 (FZD9) is a seven-transmembrane G-protein-coupled receptor that acts as a Wnt ligand-binding component in both canonical β-catenin and non-canonical signaling cascades. This unconjugated rabbit polyclonal antibody from Antibodies.com targets the receptor and is supplied at 1 mg/ml in phosphate buffered saline containing 0.05% sodium azide at approximately pH 7.2, delivered as a 100 µl vial ready for immunoblotting workflows.

The reagent detects human, mouse, and rat Frizzled-9 in Western blot applications, enabling cross-species comparison of receptor expression in cell lysates and tissue homogenates. FZD9 transduces Wnt signals that govern osteoblast differentiation and skeletal formation, shape neuronal development in the central nervous system, and modulate B-cell maturation in lymphoid tissue; altered FZD9 expression has been reported in chronic lymphocytic leukemia and other hematological malignancies. Investigators focused on Wnt pathway biology, bone biology, neurodevelopment, or lymphoid cancer research routinely use this antibody to characterize endogenous receptor levels in experimental samples.

For optimal stability, refrigerate the vial upon arrival and protect from light; for longer-term storage, aliquot and freeze at -20°C, avoiding repeated freeze-thaw cycles. The included sodium azide preservative allows convenient bench-top handling during routine Western blot protocols. Always handle with appropriate PPE and consult the lot-specific data sheet provided by Antibodies.com for validated working dilutions and recommended blocking conditions.