Anti-Frizzled-7 Antibody

Frizzled-7 (FZD7) is a seven-transmembrane G-protein-coupled receptor that serves as a primary binding partner for Wnt ligands, activating both canonical Wnt/β-catenin signaling and non-canonical pathways involved in cell proliferation, tissue patterning, and stem cell maintenance. This polyclonal rabbit reagent from Antibodies.com detects endogenous FZD7 protein across experimental systems.

Supplied as 100 µL of unconjugated antiserum, the antibody supports flexible detection workflows including pairing with HRP, fluorophore, or biotin-labeled secondary reagents. Validation covers Western blot, immunofluorescence, and ELISA applications using human and mouse samples, enabling studies in cancer biology, developmental signaling, and pathway characterization.

Frizzled-7 expression has been characterized in colorectal, gastric, and hepatocellular carcinoma tissues, where receptor upregulation contributes to tumor cell proliferation and migration. The polyclonal format offers broader epitope recognition than monoclonal alternatives, useful when probing multiple FZD7 isoforms or post-translational modifications. Store refrigerated and protect from light to preserve reagent activity across repeated experiments.