Anti-Frizzled-6 (G169) Antibody

This rabbit polyclonal antibody from Antibodies.com specifically targets Frizzled-6, a seven-transmembrane G protein-coupled receptor that functions as a Wnt ligand receptor. Frizzled-6 plays well-documented roles in planar cell polarity, neural tube closure, hair follicle orientation, and inner ear hair bundle development, and loss-of-function mutations in the corresponding gene have been linked to autosomal recessive nail dysplasia in human patients. The unconjugated reagent is supplied at 1 mg/ml in phosphate buffered saline (PBS) containing 0.05% sodium azide at approximately pH 7.2, ready for direct labeling or for use with standard secondary detection workflows. It is validated for Western blot (WB) and immunofluorescence (IF) applications and has been confirmed reactive against human, mouse, and rat samples, supporting comparative studies across model systems. Researchers apply this reagent to investigations of Wnt/β-catenin signaling, non-canonical Wnt signaling, developmental biology, and diseases involving dysregulated Frizzled activity. Each vial contains 100 µl of antibody; aliquoting upon receipt and storage at -20°C in working volumes is recommended to preserve activity across multiple experiments. The G169 epitope designation provides a clear identifier for methods sections and subsequent publications.