Anti-Fra-1 Antibody

Polyclonal antibody raised in rabbit against Fos-related antigen 1 (Fra-1), the FOSL1 transcription factor that dimerizes with JUN family members to assemble the AP-1 complex driving proliferation, differentiation, and invasion programs in mammalian cells. The reagent is supplied as 100 µl of unconjugated antiserum in a vial, validated for western blot detection of endogenous Fra-1 in cell and tissue lysates, immunohistochemistry on formalin-fixed paraffin-embedded sections, and ELISA-based quantification of protein levels. Cross-reactivity has been confirmed for human, mouse, and rat samples, enabling translational studies that compare Fra-1 expression across species and tumor models. Antibodies.com formats this polyclonal reagent for research laboratories working on AP-1-dependent signaling, epithelial-mesenchymal transition, and oncogenic transformation pathways, where elevated Fra-1 expression serves as a documented marker of poor prognosis in breast, lung, and colorectal carcinomas.