Anti-FOXP3 Antibody

This Mouse monoclonal IgG1 antibody from Antibodies.com targets human FOXP3, the forkhead box P3 transcription factor that serves as the defining lineage marker for CD4+CD25+ regulatory T cells (Tregs). Supplied as 100 µl in unconjugated format, it is validated for Western blot and immunocytochemistry on immune cell populations and tissue-derived lymphocyte preparations.

FOXP3 is required for Treg suppressive function and immune self-tolerance, and loss-of-function mutations in the gene underlie IPEX syndrome in humans. Investigators working in autoimmunity, transplant tolerance, tumor immune evasion, and chronic inflammatory disease use FOXP3 immunostaining to enumerate regulatory T cell compartments and characterize suppressive activity. The unconjugated IgG1 isotype supports flexible pairing with a broad selection of secondary antibodies and custom fluorophore or enzyme conjugation strategies, making it useful across both chromogenic and fluorescence-based detection workflows.