Anti-FOXP1 Antibody

FOXP1 (Forkhead Box P1) is a member of the FOX family of transcription factors investigated across immunology, neurobiology, and cancer research for its roles in B-cell maturation, macrophage polarization, neuronal differentiation, and recurrent involvement in B-cell lymphomas including diffuse large B-cell lymphoma (DLBCL) and MALT lymphoma, where nuclear FOXP1 expression is routinely scored as a prognostic biomarker.

This unconjugated rabbit polyclonal reagent from Antibodies.com is supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, and is validated for Western blot (WB), immunohistochemistry (IHC), and immunofluorescence (IF) workflows on human samples. The 100 µl vial supports multiple blot and slide experiments, and the glycerol-containing buffer allows storage at -20 °C with minimal freeze-thaw cycling while preserving antibody activity. Researchers use the antibody to detect the endogenous FOXP1 protein, which migrates as an approximately 75–80 kDa band in reducing SDS-PAGE Western blots, and to localize nuclear expression in formalin-fixed paraffin-embedded tissue sections as well as cultured cell lines.

Host species is rabbit, clonality is polyclonal, and the unconjugated format provides flexibility for downstream labeling with HRP, fluorophore, biotin, or gold conjugates chosen by the user. Typical applications include Western blot analysis of lymphoid and neuronal lysates, IHC on lymphoma and brain tissue microarrays, and IF imaging of nuclear FOXP1 distribution in B cells, neurons, and pluripotent stem cell-derived models.