Anti-FoxO3A (phospho-S253) Antibody

Raised in rabbit against the phosphorylated serine 253 epitope of the FoxO3A transcription factor, this polyclonal IgG reagent from Antibodies.com selectively detects the Akt/PKB-modified form of the protein. Phosphorylation at S253 drives FoxO3A nuclear export and inactivation, making this antibody a precise readout for Akt pathway activity in apoptosis, oxidative stress, cell cycle arrest, and insulin signaling studies.

The unconjugated antibody is supplied at 1 mg/ml in 100 µl of phosphate-buffered saline (pH ~7.2) containing 0.05% sodium azide, validated for western blot and immunohistochemistry on human, mouse, and rat samples. Researchers investigating tumor suppression, cardiomyocyte survival, neuronal cell death, and metabolic regulation use this reagent to monitor FoxO3A inactivation in cell lysates and formalin-fixed tissue sections. Refrigerate for storage; aliquot to avoid repeated freeze-thaw cycles and protect from light when paired with fluorescent secondary detection. For research use only.