Anti-FOXO3 (phospho S253) Antibody

Phosphorylation of FOXO3 at serine 253 is a hallmark of active PI3K/AKT signaling, and this rabbit polyclonal reagent from Antibodies.com specifically recognizes that post-translational modification. Raised against a phospho-S253 peptide, the IgG antibody is supplied as a 200 µl liquid aliquot and is validated for Western blot, immunofluorescence, and immunohistochemistry workflows. Investigators studying apoptosis, oxidative stress responses, cell-cycle exit, and the insulin/IGF-1 axis use it to monitor AKT-mediated inactivation of FOXO3 in human, mouse, and rat samples. The unconjugated format allows flexible pairing with secondary reagents of choice, and the polyclonal backbone increases the likelihood of strong signal even when the surrounding sequence context varies between species.