Anti-FoxC1 / 2 Antibody

This unconjugated rabbit polyclonal reagent targets the forkhead box transcription factors FoxC1 and FoxC2, supporting studies in developmental biology and oncology research. From Antibodies.com, the antibody is validated for western blot, immunohistochemistry, immunofluorescence, and ELISA workflows across Human, Mouse, and Rat samples.

FoxC1 and FoxC2 coordinate mesenchymal cell fate during embryogenesis, regulate lymphatic valve morphogenesis, and have been implicated in basal-like breast cancer progression, melanoma metastasis, and lymphedema-distichiasis syndrome. Researchers investigating these pathways rely on polyclonal reagents raised in rabbit to recognize conserved epitopes shared between the two paralogs.

Supplied as 100 µl of liquid in a single vial, the antibody is unconjugated, allowing flexible pairing with the secondary reporter of the user's choice. The reagent should be stored at 4 °C for short-term use and aliquoted before long-term storage at -20 °C to limit freeze-thaw damage. Each lot is quality controlled by Antibodies.com to confirm specificity toward the forkhead domain shared by FoxC1 and FoxC2.

Reactivity spans three mammalian model species—Human, Mouse, and Rat—enabling cross-species comparisons in knockout phenotyping, tumor xenograft analysis, and lymphatic tissue characterization. Working dilutions should be optimized per application, since signal intensity differs between western blot of whole-cell lysates, fixed tissue sections, and immunofluorescence of cultured cell monolayers.