Anti-FOXA2 Antibody

This rabbit polyclonal antibody from Antibodies.com targets the FOXA2 transcription factor (also called HNF-3β), a forkhead family member that functions as a chromatin-opening pioneer factor during endoderm organogenesis. Supplied as 100 µl of unconjugated IgG, the reagent is validated for Western blot, immunohistochemistry, and immunofluorescence workflows, and cross-reacts with both human and rat FOXA2 to support translational studies spanning hepatic gluconeogenesis, pancreatic islet specification, and dopaminergic neuron development relevant to Parkinson's disease models.

FOXA2 controls liver, pancreas, and lung development and continues to regulate hepatic lipid metabolism and glucose homeostasis in adult tissue, making it a frequently used marker for hepatocyte differentiation, definitive endoderm, and midbrain dopaminergic progenitors. The vial should be stored at -20 °C and aliquoted upon arrival to limit repeated freeze-thaw cycles, with the polyclonal format providing recognition of multiple FOXA2 epitopes for flexible detection across sample types.