Anti-FOXA1 Antibody

Primary antibody reagent for FOXA1 detection in research samples. This unconjugated rabbit polyclonal antibody from Antibodies.com is supplied in a 100 µl volume and validated for Western blot (WB) and immunohistochemistry (IHC) workflows on human specimens.

FOXA1 (Forkhead Box A1) functions as a pioneer transcription factor that remodels condensed chromatin and renders it accessible to lineage-specific transcription factors. It is essential for hepatic differentiation during development and is recruited to liver-specific enhancers. In oncology research, FOXA1 is widely studied as a marker and regulator in luminal breast cancer, where it cooperates with estrogen receptor α (ERα), and in prostate adenocarcinoma, where it shapes androgen receptor (AR) signaling and where its loss is associated with neuroendocrine transdifferentiation.

The reagent is provided as an unconjugated antibody suitable for use with secondary detection chemistries of the researcher's choice, including HRP, biotin, or fluorescent systems. Recommended applications include WB analysis of FOXA1 expression in cell line lysates and IHC staining of formalin-fixed paraffin-embedded tissue sections. Reactivity has been confirmed for human FOXA1. Store aliquots appropriately to preserve activity across freeze-thaw cycles.

Researchers investigating hepatic gene regulation, luminal breast cancer mechanisms, or prostate cancer lineage plasticity will find this antibody useful for probing FOXA1 protein levels and localization.