Anti-FOSB Antibody

This rabbit polyclonal antibody targets FOSB (FBJ murine osteosarcoma viral oncogene homolog B), a member of the activator protein-1 (AP-1) transcription factor family. FOSB is an immediate-early gene product that dimerizes with JUN family proteins to regulate gene expression involved in cell proliferation, differentiation, and neuronal plasticity. The unconjugated reagent from Antibodies.com is supplied in a 100 µl vial and is validated for Western blot (WB) and immunohistochemistry (IHC) applications on human samples.

Key uses include studying FOSB and its truncated, stable isoform ΔFOSB, which accumulates in the brain in response to chronic stimuli and serves as a molecular marker in addiction, depression, and chronic stress research. The antibody is also employed to investigate FOSB expression in tumor biology, where altered FOSB levels have been linked to cell cycle regulation in several cancer types.

Produced in rabbit as a polyclonal reagent, the antibody recognizes multiple epitopes on the FOSB protein, supporting reliable detection across experimental conditions. It is supplied unconjugated, enabling flexible pairing with HRP-, fluorophore-, or biotin-conjugated secondary antibodies to suit diverse detection chemistries. For long-term integrity, store frozen and prepare working aliquots to minimize freeze-thaw cycles. For research use only.