Anti-FOS (phospho T232) Antibody

Polyclonal antibody raised in rabbit against FOS phosphorylated at threonine 232, supplied as an unconjugated IgG preparation. FOS (c-Fos) is a nuclear transcription factor and core component of the AP-1 complex, where it dimerizes with JUN family proteins to regulate genes involved in cell proliferation, differentiation, and the immediate-early response to extracellular signals. Threonine 232 lies within a regulatory region whose modification by upstream kinases contributes to FOS activation downstream of MAPK/ERK signaling.

Provided by Antibodies.com in a 200 µl liquid format, this reagent is validated for Western blot (WB) and immunofluorescence (IF) applications and has been confirmed to recognize the human, mouse, and rat orthologues. Researchers studying neuronal activity mapping, stress and growth factor signaling, oncogenic transformation, and transcriptional responses to mitogenic or inflammatory cues use phospho-T232–specific FOS antibodies to distinguish the activated, kinase-phosphorylated pool of c-Fos from the total protein in cell lysates and tissue sections.