Anti-FOS B Antibody

The FOS B protein is a member of the FOS family of immediate-early transcription factors that dimerize with JUN family proteins to assemble the AP-1 (activator protein-1) complex, regulating genes involved in cell proliferation, differentiation, and stress responses. This rabbit polyclonal antibody from Antibodies.com is raised against FOS B and validated for Western Blot and Immunofluorescence / Immunocytochemistry workflows on human and mouse samples.

Supplied in an unconjugated format, the reagent pairs readily with HRP- or fluorophore-labeled secondary antibodies, allowing researchers to select detection chemistries tailored to chemiluminescent imaging or fluorescence microscopy. The 100 µL vial provides ample volume for multiple immunoblotting or IF experiments under standard protocols.

FOS B has been widely investigated in neuroscience for its contribution to reward and addiction pathways, particularly through the stable truncated isoform ΔFosB, and in cancer biology, where it can act as either an oncogene or a tumor suppressor depending on cellular context. The antibody is therefore useful for studies of neuronal plasticity, signal transduction, gene regulation, and tumor biology.

Common applications include detection of endogenous FOS B expression in cell lysates by Western Blot and visualization of subcellular localization in fixed cells by IF/ICC. For best results, store frozen at -20 °C in working aliquots and minimize freeze-thaw cycles to preserve reagent activity.