Anti-FOS Antibody

This rabbit polyclonal reagent from Antibodies.com targets FOS (c-Fos), a nuclear phosphoprotein that forms the AP-1 transcription factor complex with Jun family partners. As an immediate-early gene, FOS is rapidly induced in response to growth factors, stress signals, and neuronal depolarization, making this antibody widely used in neuroscience research as a marker of recent neuronal activity, as well as in studies of cell proliferation and differentiation.

Validated for western blot and immunohistochemistry, the unconjugated primary antibody is supplied in 100 µl format and is reactive with human, mouse, and rat samples. Produced in rabbit hosts as a polyclonal reagent, it recognizes multiple epitopes on the FOS protein, supporting robust detection across varied experimental conditions and sample preparations.

Typical research applications include mapping stimulus-evoked neuronal activity in brain tissue sections, profiling immediate-early gene responses in cell culture models, and characterizing oncogenic signaling pathways where dysregulated FOS expression has been linked to transformed cellular phenotypes and tumor progression.