Anti-FOLR1 Antibody

Folate receptor alpha (FOLR1) is a GPI-anchored membrane glycoprotein that mediates cellular uptake of folate and folate-conjugated molecules. This unconjugated rabbit polyclonal IgG from Antibodies.com recognizes the human FOLR1 protein and is validated for western blot, immunohistochemistry, and flow cytometry workflows. Researchers commonly use anti-FOLR1 antibodies to characterize folate receptor expression on epithelial tumor cells — particularly ovarian, lung, endometrial, and triple-negative breast carcinoma samples — where the receptor is frequently overexpressed relative to normal tissue.

Supplied as a 200 µl liquid aliquot, the reagent is suitable for immunoblotting of FOLR1 from cell lysates, IHC staining of formalin-fixed paraffin-embedded tissue sections to assess tumor receptor status, and flow cytometric detection of surface FOLR1 on cultured cell lines. FOLR1 is also an active clinical-translational target for antibody-drug conjugates and folate-based imaging agents, making a validated detection antibody useful for biomarker studies in ovarian and other solid tumor research programs. The polyclonal format provides recognition of multiple epitopes across the FOLR1 extracellular domain, which can be advantageous when probing samples where receptor variants or splice forms are of interest.