Anti-FOLH1 Antibody

This rabbit polyclonal antibody targets human FOLH1 (Folate Hydrolase 1), a type II transmembrane glycoprotein also known as PSMA (Prostate-Specific Membrane Antigen) and glutamate carboxypeptidase II. The unconjugated IgG reagent is supplied as 50 µl in a vial and is validated for Western blot (WB), immunohistochemistry (IHC), and immunofluorescence (IF) workflows.

FOLH1 is widely studied because of its strong overexpression in prostate epithelial cells and prostate carcinoma, while also appearing in kidney proximal tubules, small intestine, and neural tissue. Researchers use this Anti-FOLH1 reagent from Antibodies.com to investigate tumor biology, prostate cancer diagnostics, membrane protein trafficking, and the enzyme's role as a carboxypeptidase that cleaves N-acetyl-L-aspartyl-L-glutamate (NAAG).

For handling, aliquot upon receipt and store the vial at -20°C; avoid repeated freeze-thaw cycles to preserve polyclonal antibody activity. The antibody binds specifically to human FOLH1 and is not conjugated, so it can be paired with a labeled secondary reagent matched to rabbit IgG for detection in WB, IF, or IHC. The polyclonal format increases the likelihood of recognizing multiple epitopes on the FOLH1 target, which can be helpful when probing denatured samples on membranes or fixed tissue sections.