Anti-FN1 Antibody

Fibronectin 1 (FN1) is a high-molecular-weight extracellular matrix glycoprotein central to cell adhesion, integrin signaling, and wound-healing biology. This Antibodies.com reagent is a rabbit polyclonal IgG raised against FN1 and supplied as an unconjugated 100 µl aliquot, applied in Western blot (WB) and immunohistochemistry (IHC) workflows. Endogenous mouse and rat FN1 are both recognized, allowing direct comparison of fibronectin deposition across the two rodent species most commonly used in fibrosis, tumor stroma, and tissue-remodeling studies. Researchers applying it to paraffin-embedded sections can localize FN1 within basement membranes and granulation tissue, while lysate-based blots resolve full-length and proteolytic FN1 fragments under reducing conditions. The polyclonal format increases the likelihood of detecting multiple FN1 isoforms generated by alternative splicing, which is valuable when profiling ECM remodeling in disease models and experimental wound systems.