Anti-FMR1 Antibody

This unconjugated rabbit polyclonal antibody targets FMR1, the gene encoding fragile X messenger ribonucleoprotein (FMRP), an RNA-binding protein best known for its role in translational control at neuronal synapses. Loss-of-function mutations and CGG trinucleotide repeat expansion in FMR1 cause Fragile X syndrome, the leading monogenic cause of inherited intellectual disability and a widely studied model for autism spectrum research.

Validated for Western blot, immunohistochemistry, and immunofluorescence workflows, the reagent is supplied as 100 µl of polyclonal antiserum raised in rabbit and is reactive against human, mouse, and rat samples. Researchers use it to profile FMRP expression across brain regions, characterize dendritic spine localization, and investigate translational regulation in neurodevelopmental and neurodegenerative studies. The unconjugated format supports flexible downstream labeling with secondary antibodies or fluorophores of the researcher's choice.

For long-term use, aliquot upon arrival and store frozen to minimize freeze-thaw cycles; protect from light. Antibodies.com supplies this reagent as a research-use-only product intended for laboratory investigation of FMR1 biology.