Anti-Flt3 Antibody

Flt3 (also referred to as CD135) is a class III receptor tyrosine kinase that drives early hematopoiesis and the expansion of hematopoietic progenitor populations in the bone marrow. This unconjugated rabbit polyclonal reagent from Antibodies.com specifically recognizes the Flt3 target and has been validated for Western blot and ELISA workflows across human, mouse, and rat sample backgrounds.

The polyclonal antibody format broadens epitope coverage across the receptor's extracellular and intracellular regions, which is helpful for studies of ligand-dependent signaling, receptor maturation, glycosylation patterns, and surface expression on hematopoietic progenitor and leukemic cell populations. Because Flt3 is one of the most frequently mutated genes in acute myeloid leukemia, with internal tandem duplication events and tyrosine kinase domain point mutations both linked to poor prognosis, this reagent supports oncology and stem cell research programs that map pathway activation and aberrant downstream signaling.

Supplied as a 100 µl vial of unconjugated antibody, the product allows flexible pairing with user-selected secondary antibodies for chromogenic, fluorescent, or chemiluminescent Western blot detection, and with HRP-conjugated secondaries for ELISA readout. Researchers building panels around the Flt3 / FLT3 ligand axis, characterizing kinase signaling cascades, profiling leukemic cell biology, or studying bone marrow progenitor differentiation will find this reagent a useful addition to their antibody toolbox.