Anti-Flt3 Antibody

This unconjugated rabbit polyclonal reagent from Antibodies.com targets Flt3 (also known as CD135 or FLK2), a class III receptor tyrosine kinase that plays a central role in the proliferation, differentiation, and survival of hematopoietic progenitor cells in the bone marrow.

The antibody is validated for Western blot and ELISA workflows and shows reactivity against both human and mouse samples, making it a versatile tool for comparative studies in immunology, stem cell biology, and oncology research.

Because Flt3 is frequently mutated in acute myeloid leukemia (AML), particularly through internal tandem duplications (ITDs) and point mutations in the tyrosine kinase domain, this reagent supports investigations into leukemogenesis, downstream kinase signaling cascades, and the evaluation of small-molecule tyrosine kinase inhibitors.

The product is supplied as a 100 µl volume of polyclonal antiserum raised in rabbit and is suited for detection of endogenous Flt3 protein expression across cell line and primary tissue model systems.