Anti-FLT3 Antibody

FLT3 (FMS-like tyrosine kinase 3, also known as CD135) is a class III receptor tyrosine kinase expressed primarily on hematopoietic progenitor cells in the bone marrow. It plays a central role in early hematopoiesis and is among the most frequently mutated genes in acute myeloid leukemia (AML), where internal tandem duplications (ITD) and tyrosine kinase domain point mutations drive constitutive receptor activation and contribute to leukemic transformation.

This rabbit polyclonal antibody from Antibodies.com is raised against the human FLT3 protein and is supplied unconjugated in a 100 µL volume, ready to be applied directly to Western blot and immunohistochemistry workflows. It has been validated for reactivity against human samples, making it a practical tool for studies of leukemic cell lines, primary patient specimens, and formalin-fixed tissue sections from hematopoietic malignancies. Investigators commonly use this reagent to characterize FLT3 expression levels, map activation-associated phosphorylation events, and explore the relationship between receptor status and clinical outcomes in AML and related myeloproliferative disorders.