Anti-FLOT2 Antibody

This polyclonal antibody targets human FLOT2 (flotillin-2), a membrane-anchored scaffolding protein that localizes to lipid raft microdomains at the plasma membrane. Researchers apply the unconjugated reagent for Western blot and immunofluorescence workflows probing cell membrane organization, endocytic trafficking, and signaling complexes assembled on raft platforms.

The rabbit polyclonal format provides strong recognition of conserved epitopes across human, mouse, and rat samples, supporting cross-species studies of membrane biology in primary cells and established lines. Provided as a 100 µl liquid aliquot suitable for multiple immunoblotting and imaging experiments, the reagent accommodates studies ranging from fractionation analyses of detergent-resistant membrane fractions to colocalization with raft markers such as caveolin and cholesterol-binding probes.

Published investigations have used FLOT2 immunoreactivity to track membrane repair responses, characterize extracellular vesicle biogenesis, and profile metastatic phenotypes in melanoma and breast carcinoma models. Combined with Antibodies.com validation data, the antibody offers a practical tool for labs investigating insulin-stimulated GLUT4 translocation, synaptic vesicle recycling, and pathogen entry mechanisms that exploit raft domains.