Anti-FKBP6 Antibody

Raised in rabbit against the immunophilin FKBP6, this polyclonal reagent from Antibodies.com is supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, allowing direct dilution into common blotting and staining buffers. The unconjugated IgG preparation is validated for western blot, immunohistochemistry, and immunofluorescence workflows and cross-reacts with human, mouse, and rat samples, providing a single reagent for cross-species studies of meiotic chaperone biology.

FKBP6 is a tetratricopeptide-repeat immunophilin with peptidyl-prolyl isomerase activity that localizes to meiotic chromosomes, where it contributes to synaptonemal complex assembly and homologous recombination during prophase I. Researchers investigating spermatogenesis use the antibody to track FKBP6 expression in testicular tissue sections and germ cell extracts, while groups working on idiopathic male infertility screen for loss-of-function variants in patient biopsy material by western blot and immunofluorescence. The antibody has also been applied in studies of Hsp90 co-chaperone networks, where FKBP6 acts as a scaffold during client protein maturation, and in inner-ear development research probing cochlear hair cell differentiation. Each vial contains 100 µl of working-strength antibody, sufficient for multiple membrane and slide-based experiments.