Anti-FKBP52 Antibody

Produced in rabbit as an unconjugated polyclonal reagent, this Anti-FKBP52 Antibody from Antibodies.com targets the 52 kDa FK506-binding protein 52 (FKBP5 gene product), a TPR-domain co-chaperone that partners with Hsp90 to regulate steroid hormone receptor activity, microtubule dynamics, and protein folding through its PPIase domain.

Supplied in a 100 ul vial, the antibody supports western blot, immunohistochemistry, and immunofluorescence detection of endogenous FKBP52 in human samples. Researchers apply it to characterize glucocorticoid, androgen, and progesterone receptor complexes; profile stress-responsive chaperone networks; and investigate immunophilin involvement in cancer progression, neurodegeneration, and reproductive biology. The polyclonal format allows recognition of multiple epitopes, supporting studies of post-translational modifications and isoform-specific expression.

Beyond its canonical role within the Hsp90 heterocomplex, FKBP52 has been linked to tau pathology, chemoresistance mechanisms, and the cellular response to FK506 (tacrolimus), making this reagent relevant to signal transduction research, drug-target studies, and biomarker discovery in hormone-responsive tissues.