Anti-FKBP2 Antibody

Generated in rabbit and affinity-purified as a polyclonal IgG, this unconjugated primary antibody from Antibodies.com targets FKBP2, an endoplasmic reticulum-resident immunophilin that catalyzes peptidyl-prolyl cis-trans isomerization during nascent protein folding. The 200 µL format is validated for western blot (WB), immunohistochemistry (IHC), and immunofluorescence (IF) workflows, and it cross-reacts with human, mouse, and rat samples, supporting comparative studies of ER chaperone activity across mammalian model systems.

FKBP2, also known as FKBP13, has been linked to the regulation of intracellular calcium release channels and is implicated in cellular responses to ER stress and protein misfolding. Investigators working on neurodegeneration, secretory pathway biology, or immunophilin-mediated signaling can use this reagent to detect endogenous FKBP2 in fixed tissue sections, cultured cells, and prepared lysates. The polyclonal backbone allows recognition of multiple epitopes on the target, which typically improves signal consistency across varied fixation, permeabilization, and antigen retrieval conditions.

Store the antibody refrigerated at 2 to 8 degrees C and avoid repeated freeze-thaw cycles to preserve reagent performance. Aliquotting upon first use is recommended for long-term storage. Intended for research use only.