Anti-Filamin 1 Antibody

This unconjugated rabbit polyclonal antibody targets Filamin 1 (FLNA), a large ~280 kDa actin-binding protein that cross-links cortical actin filaments and anchors them to transmembrane glycoproteins. Supplied by Antibodies.com in a 100 µL volume, the polyclonal reagent is validated for Western blot, immunohistochemistry, and ELISA workflows and shows reactivity with Human, Mouse, and Rat samples, supporting cytoskeletal, cell-signalling, and developmental biology studies across mammalian model systems.

Filamin 1 functions as a versatile scaffold that tethers the actin cytoskeleton to integrins, transmembrane receptors, and downstream second-messenger pathways, and is implicated in periventricular nodular heterotopia, otopalatodigital spectrum disorders, and frontometaphyseal dysplasia when mutated. Researchers apply this antibody to investigate actin remodelling, mechanotransduction, cell migration, and FLNA subcellular localization in tissue sections and whole-cell lysates. The unconjugated format offers flexibility for pairing with user-preferred secondary antibodies or custom detection chemistries. For routine handling, refrigerate the vial; aliquot to limit freeze-thaw cycles, and protect from light for longer-term storage.