Anti-Filamin 1 Antibody

This recombinant rabbit monoclonal antibody from Antibodies.com targets Filamin 1 (FLNa), a large actin-crosslinking phosphoprotein that organizes the cortical cytoskeleton and serves as a scaffold for dozens of signaling partners and transmembrane receptors. The unconjugated reagent is supplied in a 100 µL volume in TBS (pH7.4) with 1% BSA, 40% glycerol, and 0.05% sodium azide as preservative. Listed applications cover western blot, immunocytochemistry/immunofluorescence, immunohistochemistry, and flow cytometry on human, mouse, and rat samples.

Filamin 1 research applications include mapping cytoskeletal remodeling during cell migration, characterizing FLNa–integrin and FLNa–Rho GTPase signaling complexes, profiling periventricular nodular heterotopia and otopalatodigital syndrome models, and investigating FLNa dysregulation in melanoma, breast cancer, and cardiac valve morphogenesis. The antibody also supports studies of mechanotransduction, since FLNa undergoes force-induced conformational change that exposes cryptic binding sites coupling the cytoskeleton to membrane proteins.

The monoclonal format delivers batch-to-batch consistency for longitudinal studies and reproducible signal in multiplex panels. Aliquot upon first use to minimize freeze-thaw cycles and preserve reagent activity across multiple experiments.