Anti-FGFR3 Antibody

FGFR3 (Fibroblast Growth Factor Receptor 3) is a transmembrane receptor tyrosine kinase that mediates signaling cascades controlling cell growth, differentiation, and skeletal morphogenesis. This unconjugated rabbit polyclonal reagent from Antibodies.com is supplied as a 100 µl liquid aliquot and validated for western blot and immunohistochemistry workflows across human, mouse, and rat sample types.

FGFR3 is a frequent subject in oncology research owing to its overexpression and activating mutations in bladder carcinoma, multiple myeloma, and cervical cancer, and in developmental biology studies where gain-of-function alterations are linked to achondroplasia and thanatophoric dysplasia. Investigators examining downstream MAPK and PLCγ activation, ligand-binding studies involving FGF1, FGF2, FGF8, and FGF9, or tissue distribution patterns in epithelial and cartilaginous tissues depend on robust detection reagents for this target. The polyclonal format offers reactivity against multiple epitopes, supporting reliable recognition under varied sample-preparation conditions including formalin-fixed paraffin-embedded sections for IHC and denatured lysates for western blot. For best results, refrigerate the antibody and avoid repeated freeze-thaw cycles to preserve binding activity across experiments.