Anti-FGFR2 Antibody

This unconjugated rabbit polyclonal reagent from Antibodies.com targets Fibroblast Growth Factor Receptor 2 (FGFR2), a transmembrane tyrosine kinase central to developmental signaling, tissue repair, and oncogenic transformation. Raised in rabbit and supplied at 100 µl per vial, the antibody is validated for Western blot, immunohistochemistry, and immunofluorescence workflows against human, mouse, and rat samples.

FGFR2 drives FGF-mediated cascades that regulate epithelial branching morphogenesis, osteoblast differentiation, and angiogenesis, and aberrant receptor activity is implicated in gastric, breast, and endometrial carcinomas as well as craniosynostosis syndromes including Apert and Crouzon disease. Investigators commonly apply the antibody to confirm CRISPR or siRNA knockdowns at the protein level, to profile FGFR2 distribution in tumor microarrays and patient-derived xenografts, and to localize receptor expression in fixed tissue sections or cultured cell lines under basal or ligand-stimulated conditions.

The unconjugated format leaves conjugation chemistry open, supporting on-demand labeling with fluorophores, biotin, or HRP to match downstream detection platforms. Aliquot upon receipt and store refrigerated to preserve activity across repeated experiments.