Anti-FGFR1OP Antibody

This unconjugated polyclonal reagent, supplied as 200 µl of rabbit IgG, supports Western blot investigation of the FGFR1OP centrosomal scaffold in human cell lysates. FGFR1OP, also called FOP, localizes to the centrosome throughout the cell cycle and contributes to microtubule anchoring and ciliogenesis. The protein is best known as the fusion partner that joins FGFR1 in the t(6;8) translocation underlying 8p11 myeloproliferative syndrome, which is why FGFR1OP antibodies are used alongside FGFR1 reagents to characterize stem cell leukemia/lymphoma and related atypical myeloid neoplasms. Researchers probing centrosome duplication defects, primary cilia resorption, and FGFR1-driven proliferative signaling use this antibody from Antibodies.com to confirm expression in HEK293, HeLa, and other human lines, and as a reference standard when mapping interacting partners of the FGFR1OP-FGFR1 chimera. The polyclonal format improves tolerance for minor sequence variation between isoforms, which matters when comparing endogenous FGFR1OP with fusion products carrying FGFR1-derived C-terminal extensions.