Anti-FGFR1 (phospho-Y766) Antibody

This rabbit polyclonal antibody targets fibroblast growth factor receptor 1 phosphorylated at tyrosine 766, a well-characterized autophosphorylation site involved in phospholipase C-gamma recruitment and downstream MAPK pathway activation. Provided by Antibodies.com as a primary antibody reagent, it is supplied in a 100 µl vial at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol to preserve antibody activity during storage and handling.

Validated for western blot and immunohistochemistry applications, the reagent shows reactivity against human, mouse, and rat samples, supporting cross-species studies of FGF-driven processes in development, angiogenesis, and cancer biology research. Phosphorylation at Y766 correlates with receptor activation following ligand binding, allowing researchers to monitor FGFR1 signaling dynamics in transfected cell lines, primary cell culture, and fixed tissue sections. Polyclonal reactivity provides recognition of multiple epitopes surrounding the phospho-Y766 site, which can be helpful when assessing modification states across varied sample types.

The unconjugated format enables flexible pairing with custom secondary reagents, fluorescent probes, or HRP conjugates, and supports both chromogenic and fluorescence detection protocols in single-use or batch experimental designs. Researchers commonly apply this antibody to investigate aberrant FGFR1 activation in tumor specimens, map receptor activity during embryonic development, or characterize signaling responses to small molecule inhibitors in pathway-focused studies.