Anti-FGF14 Antibody

This polyclonal antibody targets FGF14 (Fibroblast Growth Factor 14), a member of the intracellular FGF subfamily that is expressed prominently in the cerebellum, hippocampus, and other neuronal tissues. FGF14 does not act as a classical secreted growth factor; instead, it binds intracellularly to the C-terminal tail of voltage-gated sodium channels and modulates neuronal excitability, axonal targeting, and synaptic plasticity. Investigators studying spinocerebellar ataxia type 27 (SCA27), caused by FGF14 coding mutations, use this reagent to localize the protein in brain sections, primary neuronal cultures, and heterologous expression systems.

Validated for Western blot (WB), immunohistochemistry (IHC), and immunofluorescence (IF) on human, mouse, and rat samples, the reagent is supplied by Antibodies.com as a 100 µL vial at 1 mg/mL in PBS with 0.1% sodium azide and 50% glycerol as a cryoprotectant. The unconjugated rabbit polyclonal format allows flexible pairing with HRP, fluorophore, or chromogen-conjugated secondary antibodies of the researcher's choice, and the formulation supports short-term storage at 4°C with freezing and aliquoting recommended to preserve antibody activity for long-term use.