Anti-FGF-12 Antibody

Raised in rabbit, this polyclonal reagent from Antibodies.com targets FGF-12, the intracellular fibroblast growth factor also designated FHF1 (fibroblast growth factor homologous factor 1). Unlike canonical FGFs that signal through extracellular receptor activation, FGF-12 is a non-secreted member of the FGF homologous factor subfamily, predominantly expressed in the central and peripheral nervous systems where it modulates voltage-gated sodium channel function and supports neuronal excitability.

Validated for Western blot and ELISA workflows, the unconjugated IgG is supplied as a 100 µl aliquot and cross-reacts with Human, Mouse, and Rat samples, supporting comparative studies across standard model systems. The reagent suits investigations into early infantile epileptic encephalopathy and cardiac conduction disorders such as Brugada syndrome, both linked to FGF-12 mutations, as well as broader neuroscience work on sodium channel regulation and axon initial segment biology.

Because FGF-12 lacks a signal peptide and remains cytosolic, this Antibodies.com antibody is well matched to lysate-based detection rather than assays that depend on secreted analytes, and is useful for probing endogenous expression in cell lines, primary neuron cultures, and tissue homogenates.